Sano PhD Student: The Role of Structural and Functional Heterogeneity in Digital Twin Hearts

Location Krakow
Employment type Full-time
Region / State / Province małopolskie
About job:

Project title: The Role of Structural and Functional Heterogeneity in Digital Twin Hearts

Publication date:

Closing date:

Level of education required: Master's degree

Hours: 40 hours per week

Salary indication: up to PLN 8000 gross monthly


Sano: Dr Zbigniew R. Struzik (Modelling and Simulation Research Group Leader)

Project start: April 2022

Degree Awarding Institution: University of Graz

You will take part in a joint project between Sano Science Institute, University of Graz and University of Sheffield and will be guided by a world class team from these institutions. Your PhD degree will be awarded by the University of Graz.

The primary question to be addressed in this project is whether electrophysiological heterogeneity at both structural and functional levels can be incorporated in digital cohort/twin models of the whole human heart. If so, how are we to approach this in Digital Twin models considering two particular examples of inhomogeneous conductance:

i)            that due to the arrangement of myocardial fibres;

ii)           that due to the Purkinje network.

The aim is to investigate the degree to which structural and functional heterogeneity of conductance at the tissue level affects organ (system) level cardiac dynamics. To this end, methodologies should be devised with the purpose of implementing such heterogeneity using realistic parameterized models and investigating the resultant system dynamics. The phase space of system behaviour is to be discerned and quantified, including specific sensitivity to key parameters in order to provide guidelines on how to incorporate heterogeneity at tissue level in the preparation of patient specific Digital Twin Hearts.

Automatic generation methods and software tools drawing on data available from atlases, ex vivo scanning data and possible imaging techniques anticipated to be available in the near future must be prepared. This is particularly important for identifying the parameters and parameter ranges capturing most controllability/sensitivity in the system, and is thus deemed absolutely essential for the success of the personalized Digital Twin Hearts.

What are you going to do?

You are expected to:

  • do original research in this field under the direction of the supervisor;
  • participate in the many seminars by internal and external speakers, as well as journal clubs and group activities;
  • collaborate with other PhD candidates, postdoctoral researchers and Sano employees.
What do we require?

Required background and skills of the candidate:

  • Ideally a candidate should possess a 1st Class undergraduate Honours degree or a Master’s degree (completed or near completion) in a relevant discipline, such as computational mathematics (preferred), physics, biophysics, biomedical physics, or biomedical engineering with a strong mathematics background.
  • Theory and practice of numerical methods, excellent programming skills (Python, C and similar);
  • Interest in pursuing cutting edge computational biophysics research;
  • Fluency in English.
Our offer:

We offer a fixed term contract for 40 hours per week for a duration of 4 years. This will be supported by an educational plan that includes attending courses and (international) meetings. The contract will include opportunities to participate in the teaching and supervision of undergraduate and master's students.

The salary, depending on relevant experience before the beginning of the employment contract, will be up to PLN 8000 gross per month, based on a full-time contract (40 hours a week) for a duration of 4 years, plus private medical care and a sports card.

Sano offers excellent opportunities for study and development, access to many international conferences on computational medicine, and the possibility to grow in scientific society.

Last modified Monday, February 7, 2022