Sano Postdoc - Project title: Computational Drug Repurposing: a Big Data Approach to Mouse Brain Atlas for Alzheimer’s Disease

Location Krakow
Region / State / Province małopolskie
About job:

Sano Postdoc

Project title: Computational Drug Repurposing: a Big Data Approach to Mouse Brain Atlas for Alzheimer’s Disease

Publication date: 07.12.2022

Closing date: 21.12.2022

Level of education: PhD

Hours: 40 hours per week

Salary indication: up to 14000 PLN gross monthly

Supervisor:

Sano: Dr. Ahmed Abdeen Hamed (Clinical Data Science collab between student and postdoc Leader)

Project period: project starts in 2023

Brain atlas are powerful tools for learning about Alzheimer’s and the discovery of potential treatment. Particularly, mice brain atlases are of great interest in the space of drug repurposing.

Our efforts specifically focused on analyzing the biomedical literature that is publicly available in PubMed Central. We used means of text analysis, ontology term extraction, network models and algorithms to identify drug candidates and rank them. The results were validated from relevant data collected from clinical trials records. Our research also observed the possibility of drugs being combined to achieve a treatment. The full description of such discoveries is published in the JMIR and Pharmaceutics journals. Such analysis can enable the exploration of multiple layers of drugs, genes, proteins, cells, and compare it against various mouse strains.

This project strives to test the potency of drugs combinations on the brain of various model organisms.  Therefore, this project aims at the development of a multilayer mouse brain atlas as an exploratory tool to illuminate insights that could favor the treatment of Alzheimer's.

The main activities planned within this project involve the following:

•     Performing literature reviews for the state-of-the-art

•     Participate in planning, designing, architecting, testing the various development phases of the atlas

•     Perform lab test for the drug candidates that identified (in-vivo/in-vitro if needed and possible)

•     Perform data analysis, vetting, and plotting, and visualizing

•     Participate in a pair-programming activities (even without being familiar with programming)

 

This project is planned as a collaborative multi-institute, multidisciplinary that includes PhD students, Postdoctoral, and scientists from across the world.

What are you going to do?

You are expected to:

  • Contribute annotated bibliographies as basis for research on the different topics
  • Perform original research under the direction of one of Research Group Leaders;
  • Publish your work in peer-review journals and present during national and international conferences.
  • Participate in identifying proposal calls and funding opportunities
  • Participate in the efforts of outreach and collaboration with other institutes within (Poland and outside)
  • Demonstrate a comfortable level of ownership and independence
  • Co-mentor junior scientists – PhD students and MSc students (whenever applicable)

What do we require?

Required background and skills of the candidate:

  • Recent or pending PhD in relevant field, preferably computer science (no more than 5 years of postdoctoral experience).
  • At least one first-author research publication in a peer-reviewed scientific journal, top conference or currently in press.
  • Excellent written and oral English communication skills.
Our offer:

We offer a fixed term contract for 40 hours per week. This will be supported by an educational plan that includes attendance of courses and (international) meetings. The contract will include opportunities to participate in teaching and supervision of undergraduate and master students.

The salary, depending on relevant experience before the beginning of the employment contract, will be up to 14000 PLN gross per month, based on a full-time contract (40 hours a week) for the duration of up to 2 years with private medical care and a sports card.

Sano offers excellent opportunities for study and development, an access to many international conferences on computational medicine and a possibility to grow in a scientific society.

Last modified Wednesday, December 7, 2022