12/7/2022
Sano Postdoc
Project title: Computational Drug Repurposing: a Big Data Approach to Mouse Brain Atlas for Alzheimer’s Disease
Publication date: 07.12.2022
Closing date: 21.12.2022
Level of education: PhD
Hours: 40 hours per week
Salary indication: up to 14000 PLN gross monthly
Supervisor:
Sano: Dr. Ahmed Abdeen Hamed (Clinical Data Science collab between student and postdoc Leader)
Project period: project starts in 2023
Brain atlas are powerful tools for learning about Alzheimer’s and the discovery of potential treatment. Particularly, mice brain atlases are of great interest in the space of drug repurposing.
Our efforts specifically focused on analyzing the biomedical literature that is publicly available in PubMed Central. We used means of text analysis, ontology term extraction, network models and algorithms to identify drug candidates and rank them. The results were validated from relevant data collected from clinical trials records. Our research also observed the possibility of drugs being combined to achieve a treatment. The full description of such discoveries is published in the JMIR and Pharmaceutics journals. Such analysis can enable the exploration of multiple layers of drugs, genes, proteins, cells, and compare it against various mouse strains.
This project strives to test the potency of drugs combinations on the brain of various model organisms. Therefore, this project aims at the development of a multilayer mouse brain atlas as an exploratory tool to illuminate insights that could favor the treatment of Alzheimer's.
The main activities planned within this project involve the following:
• Performing literature reviews for the state-of-the-art
• Participate in planning, designing, architecting, testing the various development phases of the atlas
• Perform lab test for the drug candidates that identified (in-vivo/in-vitro if needed and possible)
• Perform data analysis, vetting, and plotting, and visualizing
• Participate in a pair-programming activities (even without being familiar with programming)
This project is planned as a collaborative multi-institute, multidisciplinary that includes PhD students, Postdoctoral, and scientists from across the world.
Location
Krakow
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